Anticoagulation is the process in which the blood becomes thinner from its original size. Anticoagulation is used to prevent or reduce the coagulation of the blood. In simple word, anticoagulation is known as the blood thinner. Anticoagulants drugs have a major role to do this.
List of Anticoagulants Drugs
There are many types of anticoagulants drugs are available such as
- Dalteparin Sodium
- Reviparin Sodium
- Coumarins and Indanediones
- Tissue-type Plasminogen Activator
- Tirofiban Hydrochloride
Anticoagulant Drugs Uses
Anticoagulants are powerful and instantaneously acting drugs, which effective both in vivo and in vitro. Anticoagulant drugs act indirectly ban y activating plasma antithrombin III and maybe another similar cofactor. The complex then binds to clotting factor Can, IIa, IXa, XIIa, and XIIIa and inactivate them.
Anticoagulant drugs act indirectly by interfering with the synthesis of Vitamin K dependent clotting factor in the liver. Drugs apparently behave as competitive antagonists of Vitamin K and reduce the plasma levels of functional clotting factor in a dose dependent manner. Plasmin acts directly on protein breaking it all the way down to win lysis.
Anticoagulant Drugs Indications
Prophylaxis of deep vein thrombosis in major surgery. Unstable coronary artery disease, that is unstable angina and non-Q-wave myocardial infarction. Treatment of acute deep venous thrombosis.
Prevention of clotting in the extra corporeal system during hemodialysis and hemofiltration in connection with acute renal failure or chronic renal insufficiency. Intraoperative and postoperative prophylaxis of deep vein thrombosis in patient with a low to moderate thrombobolic risk.
Also indicated for platelet aggregation inhibition as an adjunct to percutaneous trans tympanic coronary angioplasty or atherectomy.
Anticoagulant Drugs Dosage
Anticoagulant drugs are generally taken orally in different conditions of the patients. If the patient is not able to take those drugs orally then it could be taken as Intravenous injection slowly.
These drugs dosage can be given to neonates to adults as per their medical condition. Before use anticoagulant drugs must consult doctors or prescribed drugs.
Anticoagulant Drugs Precautions
Like coagulant drugs, these drugs are used as both orally or in Intravenous injection. Anticoagulant drugs can’t be administrated as intramuscular it is only used as an intravenous injection.
These drugs are used only under medical supervision. Special precaution should be taken for the hypertensive patient, a diabetic patient, and pregnancy. Drugs which alter platelet functions not to be used for example aspirin, and indomethacin.
Anticoagulant Drugs Side Effects
Bleeding due to overdose particularly from the skin, mucosa, wound, gastrointestinal tract, and urogenital tract. Subcutaneous hematomas at injection given sites.
Increases in serum potassium levels. On the long term use of anticoagulant drugs, osteoporosis is happens. The most common side effects are rashes on skin, fever, and diarrhea.
Anticoagulant Drugs Interactions
Concomitant medication with the effect of hemostasis, such as NSAID’s, vitamin k antagonists and dextran, may enhance the anticoagulant effect.
These drugs have more Interactions with cephalosporin’s type antibiotics. Drug Interactions increased risk of gastrointestinal bleeding with NSAID’s.